Journal article
Neonatal Maternal Separation Causes Colonic Dysfunction in Rat Pups Including Impaired Host Resistance
Abstract
Previous studies have shown that early life stress in the form of intermittent maternal separation (MS) predisposes adult rats to develop stress-induced intestinal mucosal dysfunction and visceral hypersensitivity. However, the mechanism involved in the functional abnormalities is unclear. Our aim was to study immature animals during or shortly after exposure to MS to determine whether there are early pathophysiological changes in the gut. …
Authors
Gareau MG; Jury J; Yang PC; MacQueen G; Perdue MH
Journal
Pediatric Research, Vol. 59, No. 1, pp. 83–88
Publisher
Springer Nature
Publication Date
1 2006
DOI
10.1203/01.pdr.0000190577.62426.45
ISSN
0031-3998