Anti-immunoglobulin E-stimulated ion transport in human large and small intestine

BACKGROUND: Mast-cell regulation of intestinal ion transport, previously shown in animals and cultured cells, was examined in surgically resected human bowel in this study. METHODS: Changes in short-circuit current (Isc) in response to rabbit anti-human immunoglobulin (Ig) E or control serum, histamine, and electrical stimulation were measured in muscle-stripped, noninflamed segments of intestine mounted in Ussing chambers. Chloride-free …