Gastroesophageal reflux disease and pH monitoring

Advances have been made in our understanding of the abnormalities of the lower esophageal sphincter and stomach that may initiate reflux, disorders of motility that may impair clearance of reflux material, and defense mechanisms that may protect the mucosa. There is growing interest in the association between gastroesophageal reflux disease and respiratory disorders, with clinical studies indicating its importance and physiologic studies …