Journal article
Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry
Abstract
OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with decreased top-down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (PTSD + DS) often exhibit increased mPFC top-down modulation and decreased amygdala activation associated with emotional detachment and hypoarousal. …
Authors
Nicholson AA; Friston KJ; Zeidman P; Harricharan S; McKinnon MC; Densmore M; Neufeld RWJ; Théberge J; Corrigan F; Jetly R
Journal
Human Brain Mapping, Vol. 38, No. 11, pp. 5551–5561
Publisher
Wiley
Publication Date
11 2017
DOI
10.1002/hbm.23748
ISSN
1065-9471