Laboratory diagnosis of immune heparin-induced thrombocytopenia.

Immune heparin-induced thrombocytopenia (HIT) is a distinct immunohematologic syndrome in which laboratory detection of the pathogenic HIT antibodies is diagnostically useful. Assays can be broadly classified as platelet activation assays (which detect HIT antibodies based on their characteristic platelet-activating properties) and antigen assays (which measure antibodies reactive against platelet factor 4 complexed with heparin or other …