Journal article
Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients.
Abstract
AIMS: The MLL gene on chromosome 11q23 is frequently disrupted by chromosomal translocations in association with haematological malignancies. Recently, a specific site within the 8.3 kb MLL break-point cluster region that is cleaved during the early stages of apoptosis has been identified. Because MLL gene rearrangements are used to identify patients with high risk leukaemia, it was the aim of this study to determine whether this DNA cleavage …
Authors
Stanulla M; Schünemann HJ; Thandla S; Brecher ML; Aplan PD
Journal
Molecular Pathology, Vol. 51, No. 2,
Publisher
BMJ
Publication Date
4 1998
DOI
10.1136/mp.51.2.85
ISSN
1366-8714
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Blotting, SouthernBone MarrowChildChromosomes, Human, Pair 11CryopreservationCulture TechniquesDNA-Binding ProteinsFemaleGene RearrangementHistone-Lysine N-MethyltransferaseHumansInfantLeukemiaMaleMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-OncogenesSpecimen HandlingTranscription FactorsZinc Fingers