Journal article
Relation of Distribution- and Anchor-Based Approaches in Interpretation of Changes in Health-Related Quality of Life
Abstract
BACKGROUND: Approaches to interpretation of quality of life changes in clinical trials have fallen into two camps: those that rely on the distribution of changes and the Effect Size (ES), and those that use some external anchor, such as patient judgments of change, which is then used to compute a Minimally Important Difference (MID), the proportion benefiting from treatment, p(B), and the Number Needed to Treat (NNT).
OBJECTIVE: To examine the …
Authors
Norman GR; Sridhar FG; Guyatt GH; Walter SD
Journal
Medical Care, Vol. 39, No. 10, pp. 1039–1047
Publisher
Wolters Kluwer
Publication Date
10 2001
DOI
10.1097/00005650-200110000-00002
ISSN
0025-7079