Journal article
Are large clinical trials in orthopaedic trauma justified?
Abstract
BackgroundThe objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data.MethodsThe FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pressures on re-operation. To explore treatment effects over time, we analyzed data from the pilot and definitive trial in increments of 250 patients until the final sample size of 2447 patients was …
Authors
Sprague S; Tornetta P; Slobogean GP; O’Hara NN; McKay P; Petrisor B; Jeray KJ; Schemitsch EH; Sanders D; Bhandari M
Journal
BMC Musculoskeletal Disorders, Vol. 19, No. 1,
Publisher
Springer Nature
Publication Date
12 2018
DOI
10.1186/s12891-018-2029-3
ISSN
1471-2474