Journal article
The Role of AMPK in Neuromuscular Biology and Disease
Abstract
AMP-activated protein kinase (AMPK) is a primary regulator of cellular metabolism. Recent studies have revealed that AMPK also mediates the maintenance and plasticity of α-motoneurons, the neuromuscular junction, and skeletal muscle. Furthermore, AMPK stimulation by either genetic, pharmacological, or physiological approaches elicits beneficial phenotypic remodeling in neuromuscular disorders (NMDs). Here, we review the role of AMPK as a …
Authors
Dial AG; Ng SY; Manta A; Ljubicic V
Journal
Trends in Endocrinology and Metabolism, Vol. 29, No. 5, pp. 300–312
Publisher
Elsevier
Publication Date
May 2018
DOI
10.1016/j.tem.2018.02.010
ISSN
1043-2760