Journal article
Trophoblast CD200 expression in successful human pregancies and missed abortions
Abstract
Presence of the CD200 immune check-point inhibitor at the feto-maternal interface is linked to prevention of spontaneous abortion in mice and humans. In human missed abortions (MA), absence of Th17-driven inflammation has been attributed to expression of villus trophoblast CD200 quantified using immunohistochemistry. While rapid aneuploidy (QF-PCR) testing linked low CD200 to pregnancy failure, data showing normal VT CD200 in first trimester …
Authors
Clark DA; McCready ME; Harris K; Malloy L; Arredondo JL
Journal
Journal of Reproductive Immunology, Vol. 127, , pp. 55–57
Publisher
Elsevier
Publication Date
6 2018
DOI
10.1016/j.jri.2018.03.001
ISSN
0165-0378