Journal article
Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity
Abstract
BackgroundThe NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival during endotoxemia and experimental sepsis. However, the underlying protective mechanism remains elusive.ResultEP dose-dependently inhibited the …
Authors
Li S; Liang F; Kwan K; Tang Y; Wang X; Tang Y; Li J; Yang H; Chavan SS; Wang H
Journal
Molecular Medicine, Vol. 24, No. 1,
Publisher
Springer Nature
Publication Date
12 2018
DOI
10.1186/s10020-018-0006-9
ISSN
1076-1551