Journal article
Critical concepts in adaptive clinical trials
Abstract
Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical trials as they allow modifications to key trial design …
Authors
Park JJ; Thorlund K; Mills EJ
Journal
Clinical Epidemiology, Vol. 10, No. 0, pp. 343–351
Publisher
Taylor & Francis
Publication Date
March 23, 2018
DOI
10.2147/clep.s156708
ISSN
1179-1349