Journal article
Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier
Abstract
More than 40% of HIV infections occur via female reproductive tract (FRT) through heterosexual transmission. Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens. These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses. Previously, we have shown that in response to HIV-1 gp120, the …
Authors
Nazli A; Dizzell S; Zahoor MA; Ferreira VH; Kafka J; Woods MW; Ouellet M; Ashkar AA; Tremblay MJ; Bowdish DM
Journal
Cellular & Molecular Immunology, Vol. 16, No. 2, pp. 178–194
Publisher
Springer Nature
Publication Date
2 2019
DOI
10.1038/cmi.2017.168
ISSN
1672-7681