Journal article
Follicle growth is inhibited by benzo-[a]-pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay
Abstract
BACKGROUND: The adverse effects of cigarette smoking on human fertility have been well documented. However, the mechanism(s) underlying the detrimental effects of cigarette smoking are unknown. Using a novel isolated rat follicle culture assay, we tested the hypothesis that benzo-[a]-pyrene (B[a]P), a constituent of cigarette smoke, can inhibit follicle growth.
METHODS: B[a]P levels were quantified in the serum and follicular fluid (FF) of …
Authors
Neal MS; Zhu J; Holloway AC; Foster WG
Journal
Human Reproduction, Vol. 22, No. 4, pp. 961–967
Publisher
Oxford University Press (OUP)
Publication Date
April 1, 2007
DOI
10.1093/humrep/del487
ISSN
0268-1161