Journal article
Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma
Abstract
Over 70% of head & neck squamous cell carcinoma (HNSCC) patients carry TP53 oncogenic mutations. Here we studied the role of specific tumor-derived mutant p53 proteins in the aberrant transcription of long non-coding (lnc) MIR205HG gene in head and neck cancer cells. Methods: To understand the role of lncMIR205HG, that we showed to be transcriptionally regulated by mutant p53 in HNSCC, we have employed siRNA and shRNA in CAL27 and FaDu HNSCC …
Authors
Di Agostino S; Valenti F; Sacconi A; Fontemaggi G; Pallocca M; Pulito C; Ganci F; Muti P; Strano S; Blandino G
Journal
Theranostics, Vol. 8, No. 7, pp. 1850–1868
Publisher
Ivyspring International Publisher
DOI
10.7150/thno.22167
ISSN
1838-7640
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Cell Line, TumorCell ProliferationChromatin ImmunoprecipitationGene Expression ProfilingGene Regulatory NetworksGene SilencingHumansMicroRNAsMutant ProteinsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSquamous Cell Carcinoma of Head and NeckTumor Suppressor Protein p53