17β-Estradiol Supplementation Decreases Glucose Rate of Appearance and Disappearance with No Effect on Glycogen Utilization during Moderate Intensity Exercise in Men

CONTEXT AND OBJECTIVE: Women use less carbohydrate during endurance exercise, as compared with men. In rodents, 17beta-estradiol (E2) supplementation robustly increases lipid use and lowers muscle and liver glycogen use during exercise. E2 supplementation has been found to influence substrate selection by decreasing glucose rate of appearance (Ra), disappearance (Rd), and metabolic clearance rate during exercise in humans; however, neither a …