Journal article
ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice
Abstract
CSB, a member of the SWI2/SNF2 superfamily, is implicated in DNA double-strand break (DSB) repair. However, how it regulates this repair process is poorly understood. Here we uncover that CSB interacts via its newly identified winged helix domain with RIF1, an effector of 53BP1, and that this interaction mediates CSB recruitment to DSBs in S phase. At DSBs, CSB remodels chromatin by evicting histones, which limits RIF1 and its effector MAD2L2 …
Authors
Batenburg NL; Walker JR; Noordermeer SM; Moatti N; Durocher D; Zhu X-D
Journal
Nature Communications, Vol. 8, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-017-02114-x
ISSN
2041-1723
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid MotifsAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCell Line, TumorChromatin Assembly and DisassemblyCyclin ACyclin-Dependent Kinase 2DNA Breaks, Double-StrandedDNA HelicasesDNA RepairDNA Repair EnzymesHCT116 CellsHumansMad2 ProteinsPhosphorylationPoly-ADP-Ribose Binding ProteinsS PhaseTelomere-Binding ProteinsTumor Suppressor p53-Binding Protein 1