Journal article
Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering
Abstract
OBJECTIVE: Rosuvastatin has been widely used in the primary and secondary prevention of coronary heart disease. However, its antiatherosclerotic properties have not been tested in a mouse model that could mimic human coronary heart disease. The present study was designed to test the effects of rosuvastatin on coronary artery atherosclerosis and myocardial fibrosis in SR-B1 (scavenger receptor class B type 1) and apoE (apolipoprotein E) double …
Authors
Yu P; Xiong T; Tenedero CB; Lebeau P; Ni R; MacDonald ME; Gross PL; Austin RC; Trigatti BL
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 38, No. 1, pp. 26–39
Publisher
Wolters Kluwer
Publication Date
January 2018
DOI
10.1161/atvbaha.117.305140
ISSN
1079-5642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAortic DiseasesAtherosclerosisBiomarkersCells, CulturedCholesterolCoronary Artery DiseaseCoronary VesselsDisease Models, AnimalFoam CellsHydroxymethylglutaryl-CoA Reductase InhibitorsLipoproteins, LDLLiverMice, Knockout, ApoEPlaque, AtheroscleroticProprotein Convertase 9Receptors, LDLRosuvastatin CalciumScavenger Receptors, Class BSinus of Valsalva