Journal article
CD8+ T-cell-mediated suppression of HIV-1 long terminal repeat-driven gene expression is not modulated by the CC chemokines RANTES, macrophage inflammatory protein (MIP)-1α and MIP-1β
Abstract
OBJECTIVE: To assess the role of RANTES, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in modulation of HIV-1 long terminal repeat (LTR)-mediated gene expression and determine whether these chemokines share identity with CD8+ T-lymphocyte-derived HIV-1 LTR-suppressive factors.
DESIGN: HIV-1 LTR-directed reporter gene expression is a model for transcription that is susceptible to inhibition by factors produced by CD8+ lymphocytes …
Authors
Leith JG; Copeland KFT; McKay PJ; Richards CD; Rosenthal KL
Journal
AIDS, Vol. 11, No. 5, pp. 575–580
Publisher
Wolters Kluwer
Publication Date
4 1997
DOI
10.1097/00002030-199705000-00004
ISSN
0269-9370