Journal article
Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene
Abstract
This study explores and characterizes the toxicity of two closely related carcinogenic dinitro-pyrenes (DNPs), 1,3-DNP and 1,8-DNP, in human bronchial epithelial BEAS-2B cells and mouse hepatoma Hepa1c1c7 cells. Neither 1,3-DNP nor 1,8-DNP (3-30 μM) induced cell death in BEAS-2B cells. In Hepa1c1c7 cells only 1,3-DNP (10-30 μM) induced a mixture of apoptotic and necrotic cell death after 24 h. Both compounds increased the level of reactive …
Authors
Holme JA; Nyvold HE; Tat V; Arlt VM; Bhargava A; Gutzkow KB; Solhaug A; Låg M; Becher R; Schwarze PE
Journal
Toxicology Reports, Vol. 1, , pp. 459–473
Publisher
Elsevier
Publication Date
2014
DOI
10.1016/j.toxrep.2014.07.009
ISSN
2214-7500