Journal article
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Abstract
Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci are also associated with CHD and that greater genetic risk of T2D increases risk of CHD.
Authors
Zhao W; Rasheed A; Tikkanen E; Lee J-J; Butterworth AS; Howson JMM; Assimes TL; Chowdhury R; Orho-Melander M; Damrauer S
Journal
Nature Genetics, Vol. 49, No. 10, pp. 1450–1457
Publisher
Springer Nature
Publication Date
October 1, 2017
DOI
10.1038/ng.3943
ISSN
1061-4036
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AsiaAsian PeopleBiomarkersComorbidityCoronary DiseaseDiabetes Mellitus, Type 2EuropeGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-DRB5 ChainsHumansMetabolic Networks and PathwaysMetabolic SyndromeMolecular Targeted TherapyMutation, MissensePolymorphism, Single NucleotideRisk FactorsWhite People