Membrane reactor for continuous and selective protein mono-PEGylation

PEGylated proteins are value-added biopharmaceutical products obtained by conjugating poly (ethylene glycol) or PEG with proteins. It is difficult to simultaneously obtain both high selectivity and extent of synthesis of mono-PEGylated protein using a conventional batch reaction. This paper discusses a hollow-fiber membrane reactor (HMR) system suitable for addressing this issue. The HMR system was operated in a continuous mode with the protein …