Fractionation of human plasma proteins by hydrophobic interaction membrane chromatography

This paper discusses the fractionation of human plasma proteins HSA and HIgG by hydrophobic interaction membrane chromatography. A type of microporous polyvinylidine fluoride (PVDF) membrane having 0.1μm pore size was identified as being suitable for carrying out this separation. This membrane bound HIgG at 1.5M ammonium sulphate concentration, a condition at which HSA did not. Based on this selective binding resulting from the selective …