Journal article
Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice
Abstract
Lipoprotein metabolism is an important contributing factor in the development and progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily glycosylated and sialylated, and levels of sialic acids modulate their biological functions. Sialylation is controlled by the activities of sialyltranferases and sialidases. To address the impact of sialidase (neu1) activity on lipoprotein metabolism, we have generated a mouse …
Authors
Yang A; Gyulay G; Mitchell M; White E; Trigatti BL; Igdoura SA
Journal
Journal of Lipid Research, Vol. 53, No. 12, pp. 2573–2585
Publisher
Elsevier
Publication Date
12 2012
DOI
10.1194/jlr.m027300
ISSN
0022-2275