Effect of anti-TGF-β2 surface modification of polydimethylsiloxane on lens epithelial cell markers of posterior capsule opacification

Posterior capsule opacification is the most common complication of cataract surgery. Lens epithelial cells remaining in the capsular bag following surgery can undergo epithelial-to-mesenchymal transition and migrate from the anterior to the posterior capsule, leading to fibrosis, capsular wrinkling, and ultimately vision loss. Transforming growth factor-beta 2 has been shown to play a major role in epithelial-to-mesenchymal transition. Covalent …