A new t-PA releasing concept based on protein–protein displacement

A new tissue plasminogen activator (t-PA) releasing concept based on a unique protein-displacement triggering mechanism is reported. This concept takes advantage of the fact that plasminogen has higher affinity than t-PA for surface bound lysine. t-PA bound to lysine-modified materials through specific interactions is thus displaced from the surface (released) by plasminogen when in contact with plasma. The concept was investigated using a …