Journal article
Plasma Concentrations and Genetic Variation of Matrix Metalloproteinase 9 and Prognosis of Patients With Cardiovascular Disease
Abstract
BACKGROUND: Matrix metalloproteinase (MMP)-9 secretion by macrophages and other inflammatory cells accelerates atherosclerotic progression and destabilizes vulnerable plaque in animal models. However, epidemiological data evaluating the prognostic impact of circulating concentrations and functional genetic variations of MMP-9 are lacking.
METHODS AND RESULTS: In a prospective study of 1127 patients with documented coronary artery disease, we …
Authors
Blankenberg S; Rupprecht HJ; Poirier O; Bickel C; Smieja M; Hafner G; Meyer J; Cambien F; Tiret L
Journal
Circulation, Vol. 107, No. 12, pp. 1579–1585
Publisher
Wolters Kluwer
Publication Date
4 2003
DOI
10.1161/01.cir.0000058700.41738.12
ISSN
0009-7322