Process Analytical Technology Beyond Real-Time Analyzers: The Role of Multivariate Analysis

Process analytical chemistry was recognized by Callis et al. (Analytical Chemistry, 59 (1987): 624A–635A) (1) as a field that extends well beyond real time measurements of process parameters. Process Analytical Technology is taking central stage with the 2004 guidance from the Food and Drug Administration, with a mandate much wider than real time measurements. The pharmaceutical industry is entering a new era. Chemometrics has played an …