Journal article
Selective cytotoxicity of gemcitabine in bladder cancer cell lines
Abstract
We have examined the cytotoxic effect of gemcitabine in intravesical therapy using an in vitro co-cultured spheroid model composed of transitional cell carcinoma (TCC) and fibroblasts from both human and rat species. Immunohistochemistry analysis of the co-cultured spheroids, using cytokeratin-13 and vimentin antibodies against TCC and fibroblasts, respectively, showed the central location of fibroblasts within the spheroid, whereas TCC formed …
Authors
Kilani; Tamimi Y; Karmali S; Mackey J; Hanel E; Wong K; Moore R
Journal
Anti-Cancer Drugs, Vol. 13, No. 6, pp. 557–566
Publisher
Wolters Kluwer
Publication Date
July 2002
DOI
10.1097/00001813-200207000-00002
ISSN
0959-4973