Treatment of Delusions in Dementia with Lewy Bodies – Response to Pharmacotherapy

BACKGROUND: Delusions are clinically important symptoms in dementia with Lewy bodies (DLB). The purpose of this review is to examine the level of evidence for treatment of delusions in DLB. METHODS: To achieve this objective Medline was searched. Studies were included in the review if they were prospective, separated delusions from hallucinations and were tested in patients with DLB. RESULTS: The review yielded a total of six studies. Although all studies showed effectiveness, only one study using rivastigmine had an adequate patient sample size and used a randomized controlled design. CONCLUSION: Further studies are required before a definitive conclusion can be reached about effective treatments.