selected scholarly activity
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conferences
- Absence of deferiprone-induced hepatic fibrosis: A multi-center study.. Blood. 606A-+. 2000
- Foundation science for medicine in the 21st century. Proceedings of a workshop. Hamilton, Ontario, Canada. May 21-23, 1999.. Clinical and Investigative Medicine. 5-108. 2000
- Closing remarks. Clinical and Investigative Medicine. 37-38. 2000
- Discussion. Clinical and Investigative Medicine. 52-54. 2000
- Discussion. Clinical and Investigative Medicine. 35-36. 2000
- Discussion. Clinical and Investigative Medicine. 45-46. 2000
- Report on the 1997 Annual Meeting of the Association of Canadian Medical Colleges, the Association of Canadian Teaching Hospitals and the Canadian Association for Medical Education: Introduction. Clinical and Investigative Medicine. 397-398. 1997
- MICROSOMAL CHEMILUMINESCENCE (LIPID-PEROXIDATION) IS STIMULATED BY OXYGEN IN THE PRESENCE OF ANAEROBICALLY RELEASED FERRITIN IRON. The FASEB Journal. 1746-1746. 1986
- IMMUNOREGULATION BY DIOXIN AND RELATED HALOAROMATIC HYDROCARBONS. Journal of Leukocyte Biology. 392-392. 1984
- SELECTIVE SUPPRESSION OF CYTO-TOXIC T-CELL (CTL) GENERATION BY HALOGENATED AROMATIC-HYDROCARBONS. The FASEB Journal. 1096-1096. 1981
- IRON-DEFICIENCY PREVENTS LIVER TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN. The FASEB Journal. 536-536. 1979
- HETEROGENEITY OF RAT-LIVER PARENCHYMAL-CELLS STUDIED USING SEDIMENTATION-VELOCITY ANALYSIS. Gastroenterology. 1249-1249. 1977
- HETEROGENEITY OF SIZE AND FUNCTION IN HEPATOCYTES - EFFECTS OF 3-METHYL CHOLANTHRENE (3-MC) AND PHENOBARBITAL (PB). The FASEB Journal. 960-960. 1977
- PATHOGENESIS OF PORPHYRIA CUTANEA-TARDA (PCT). Gastroenterology. 1227-1227. 1977
- FETAL ERYTHROPOIESIS IN FLEXED TAILED MUTANT (F/F) MICE. The FASEB Journal. 365-365. 1976
- HEXACHLOROBENZENE (HCB) PORPHYRIA IN RATS - DIFFERENCE BETWEEN SEXES. PHARMACOLOGIST. 245-245. 1976
- RELATIVE DEFICIENCY OF CYTOCHROME P450 AND ARYL-HYDROCARBON HYDROXYLASE (AHH) IN HYPERPLASTIC NODULES INDUCED BY ACETYLAMINOFLUORENE IN RAT-LIVER. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting. 36-36. 1976
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journal articles
- Deferiprone and hepatic fibrosis. Blood. 101:5089-5091. 2003
- Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. Blood. 100:1566-1569. 2002
- Clinical and investigative medicine: In this issue. Clinical and Investigative Medicine. 23:300-301. 2000
- "Give us good measure": the basic medical sciences and the overloaded curriculum - Discussion. Clinical and Investigative Medicine. 23:45-46. 2000
- Basic science and medical education: dinosaurs, departments and definitions - a McMaster view - Discussion. Clinical and Investigative Medicine. 23:35-36. 2000
- Evaluation: the engine that drives us forward - or back - Discussion. Clinical and Investigative Medicine. 23:78-80. 2000
- Foundation science for medicine in the 21st century - Foreword. Clinical and Investigative Medicine. 23:5-6. 2000
- Foundation science for medicine: a family medicine perspective - Discussion. Clinical and Investigative Medicine. 23:97-98. 2000
- The essential role of basic science in medical education: the perspective from psychology - Discussion. Clinical and Investigative Medicine. 23:52-54. 2000
- The state of play in 1999 - Closing remarks. Clinical and Investigative Medicine. 23:37-38. 2000
- The student's perspective - Discussion. Clinical and Investigative Medicine. 23:105-105. 2000
- Discussion. Clinical and Investigative Medicine. 23:105. 2000
- Discussion. Clinical and Investigative Medicine. 23:78-80. 2000
- Discussion. Clinical and Investigative Medicine. 23:97-98. 2000
- Discussion. Clinical and Investigative Medicine. 23:84-85. 2000
- Two solitudes.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 160:181-182. 1999
- Dr. Cornelia Wieman is the 1998 medical award recipient. Clinical and Investigative Medicine. 21:52-52. 1998
- The National Aboriginal Achievement Awards. Dr. Cornelia Wieman is the 1998 medical award recipient.. Clinical and Investigative Medicine. 21:52-53. 1998
- Report on ACMC Annual Meeting - Introduction. Clinical and Investigative Medicine. 20:397-398. 1997
- The learning environment and the clinician scientist.. Clinical and Investigative Medicine. 20:248. 1997
- Bill C-91: the debate continues.. Clinical and Investigative Medicine. 20:193-195. 1997
- Ethanolamine and choline phospholipids in nascent very-low-density lipoprotein particles.. Clinical and Investigative Medicine. 19:243-250. 1996
- High Blood Alcohol Levels in Women. New England Journal of Medicine. 323:58-62. 1990
- PHARMACOKINETICS OF CARBETOCIN, A LONG-ACTING OXYTOCIN ANALOG, IN NONPREGNANT WOMEN. Current Therapeutic Research - Clinical and Experimental. 47:528-540. 1990
- Anti-Allergy and Anti-Asthma Drugs. Clinical Pharmacokinetics. 17:156-168. 1989
- DRUG DISPOSITION IN INFANCY AND CHILDHOOD SEMINAR-IN-PRINT - ROUND-TABLE DISCUSSION. Clinical Pharmacokinetics. 17:169-176. 1989
- Delayed, ferrous iron-dependent peroxidation of rat liver microsomes. Molecular Cell Biology Research Communications. 259:372-381. 1987
- The pharmacokinetics of isoxicam in elderly patients with rheumatoid arthritis. Current Medical Research and Opinion. 10:580-591. 1987
- Lowering of plasma isoxicam concentrations with acetylsalicylic acid.. Journal of Rheumatology. 13:1119-1121. 1986
- Lipid peroxidation stimulated by iron nitrilotriacetate in rat liver. Biochemical Pharmacology. 35:2381-2387. 1986
- Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseases. Clinical Biochemistry. 19:3-15. 1986
- The role of contaminants in hexachlorobenzene toxicity.. IARC (International Agency for Research on Cancer) Scientific Publications. 363-370. 1986
- Experimental porphyria. Clinics in Dermatology. 3:125-143. 1985
- Interaction of human lactoferrin with the rat liver. American Journal of Physiology. 248:G463-G469. 1985
- A simple bioassay for monocyte-derived hepatocyte stimulating factor: Increased synthesis of α2-macroglobulin and reduced synthesis of albumin by cultured rat hepatocytes. Immunotechnology : an international journal of immunological engineering. 76:317-327. 1985
- INTERACTION OF HUMAN LACTOFERRIN WITH THE RAT-LIVER. American Journal of Physiology. 248:G463-G469. 1985
- Release of ferrous iron from ferritin by liver microsomes: a possible role in the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry and Cell Biology. 62:1293-1300. 1984
- The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines. Biochemical Journal. 224:505-514. 1984
- Sensitivity to suppression of cytotoxic T cell generation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the Ah genotype of the murine host. Toxicology and Applied Pharmacology. 72:169-176. 1984
- Ferric nitrilotriacetate: A potent stimulant of lipid peroxidation in mice. Biochemical Pharmacology. 32:3879-3882. 1983
- The role of proteolytic enzymes derived from crude bacterial collagenase in the liberation of hepatocytes from rat liver. The FEBS Journal. 137:311-318. 1983
- Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons. Immunopharmacology. 6:143-153. 1983
- Variability in the human drug response. Thrombosis Research. 29:3-15. 1983
- Enhanced Suppressor Cell Activity as a Mechanism of Immunosuppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Experimental Biology and Medicine. 168:290-299. 1981
- The role of iron in the toxicity of 2,3,7,8-tetrachlorodibenzo-(p)-dioxin (TCDD). Toxicology and Applied Pharmacology. 61:74-88. 1981
- Drugs???some basic concepts. Medicine & Science in Sports & Exercise. 13:247-251. 1981
- Functional heterogeneity among liver cells: implications for drug toxicity and metabolism. Trends in Pharmacological Sciences. 2:141-144. 1981
- Selective suppression of cytotoxic T cell (CTL) generation by halogenated aromatic hydrocarbons. The FASEB Journal. 40. 1981
- 'MacDope': a simulation of drug disposition in the human body: applications in clinical pharmacokinetics.. British Journal of Clinical Pharmacology. 10:591-602. 1980
- MacDope: A simulation of drug disposition in the human body. Mathematical considerations. Journal of Theoretical Biology. 87:211-236. 1980
- Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness. Toxicology and Applied Pharmacology. 53:42-49. 1980
- Changes in rat hepatocyte plasma membranes caused by synthetic estrogens.. Laboratory Investigation. 42:225-230. 1980
- Effects of ethynyl estradiol on liver microsomal mixed function oxygenase activity in male rats.. Laboratory Investigation. 42:231-235. 1980
- Heterogeneity of rat liver parenchymal cells: cell volume as a function of DNA content.. Translational Research. 94:718-725. 1979
- Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo- p -Dioxin. Science. 204:332-335. 1979
- Porphyria cutanea tarda: clinical and laboratory features.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 120:803-807. 1979
- Application of a pharmacokinetic simulation program in pharmacy courses. Computers & Education. 3:335-345. 1979
- Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. The FASEB Journal. 38. 1979
- Quantitation of urinary porphyrins by use of second-derivative spectroscopy.. Clinical Chemistry. 25:71-74. 1979
- Effects of phenobarbital and 3-methylcholanthrene pretreatment on size, sedimentation velocity, and mixed function oxygenase activity of rat hepatocytes.. Translational Research. 91:444-454. 1978
- Studies using sedimentation velocity on heterogeneity of size and function of hepatocytes from mature male rats.. Translational Research. 91:432-443. 1978
- Association between induction of aryl hydrocarbon hydroxylase and depression of uroporphyrinogen decarboxylase activity.. Research Communications in Molecular Pathology and Pharmacology. 17:631-637. 1977
- Hemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice. Blood. 50:165-177. 1977
- Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes. Canadian Journal of Physiology and Pharmacology. 54:844-849. 1976
- A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.. Cancer Research. 36:3888-3893. 1976
- A novel electrophoretic pattern of induction of rat liver microsomal membrane polypeptides by 2-acetylaminofluorene, nitrosamine and azo dye administration. Biochemical and Biophysical Research Communications. 71:1054-1061. 1976
- Measurement of urine porphyrins and porphyrinogens. Molecular Genetics and Metabolism. 15:223-232. 1976
- RELATIVE DEFICIENCY OF CYTOCHROME-P-450 AND ARYL-HYDROCARBON [BENZO(A)PYRENE] HYDROXYLASE IN HYPERPLASTIC NODULES INDUCED BY 2-ACETYLAMINOFLUORENE IN RAT-LIVER. Cancer Research. 36:3888-3893. 1976
- Hepatic metabolism of hexachlorobenzene in rats. FEBS Letters. 51:225-226. 1975
- Use of Hypnotics. New England Journal of Medicine. 292:217-218. 1975
- An introduction to the study of medicine. Academic Medicine. 50:70-7. 1975
- Erythrocyte Coproporphyrin and Protoporphyrin in Ethanol-induced Sideroblastic Erythropoiesis. Blood. 43:291-295. 1974
- Spectroscopic evidence of interaction between 2-allyl-2-isopropylacetamide and cytochrome P-450 of rat liver microsomes. Biochemical and Biophysical Research Communications. 55:798-804. 1973
- Evidence against a regulatory role for heme oxygenase in hepatic heme synthesis. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 304:871-874. 1973
- Decrease in hepatic cytochrome P-450 and catalase following allylisopropylacetamide: The effect of concomitant hemin administration. Biochemical and Biophysical Research Communications. 47:1366-1371. 1972
- Experimental porphyria. I. The experimental porphyrias--a group of distinctive metabolic lesions.. Southern African Journal of Critical Care. 68-72. 1971
- The acute porphyric attack. I. The electrolyte disorder of the acute porphyric attack and the possible role of delta-aminolaevulic acid.. Southern African Journal of Critical Care. 89-97. 1971
- Quantitative estimation of tryptophan in plasma and urine using thin-layer chromatography (TLC) and induced fluorescence. Clinica Chimica Acta. 17:317-323. 1967
- Analysis of porphyrin methyl esters by thin-layer chromatography and fluorimetric scanning.. Southern African Journal of Critical Care. 41:460-463. 1967
- The diagnostic importance of faecal porphyrins in the differentiation of the porphyrias. 3. South African genetic porphyria (variegcte porphyria)--the acute attack.. Southern African Journal of Critical Care. 40:380-382. 1966
- Hypothesis: the nature of dominantly inherited metabolic diseases.. Southern African Journal of Critical Care. 39:1075. 1965
- Effects of Chloroquine on Patients with Cutaneous Porphyria of the "Symptomatic" Type. The BMJ. 1:1281-1285. 1965
- The Determination of Coproporphyrin Isomers. Scandinavian Journal of Clinical and Laboratory Investigation, Supplement. 16:250-251. 1964
- ERYTHROPOIETIC PROTOPORPHYRIA. A BRIEF REPORT OF THE FIRST SOUTH AFRICAN CASE.. South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk. 14:247-249. 1963
- PATTERNS OF PORPHYRIN EXCRETION IN SOUTH AFRICA PORPHYRIC PATIENTS.. South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk. 14:182-190. 1963
- PRESENTATION OF PATIENTS WITH PORPHYRIA.. South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk. 14:162-176. 1963
- THE DIAGNOSTIC IMPORTANCE OF FAECAL PORPHYRINS IN THE DIFFERENTIATION OF THE PORPHYRIAS. II. VALUES IN THE CUTANEOUS PORPHYRIAS.. South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk. 18:126-134. 1963
- The extraction and purification of faecal porphyrins.. South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk. 9:81-86. 1963
- PORPHYRIA. The Lancet. 278:213-214. 1961