selected scholarly activity
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chapters
- DEFICIENT REPLICATION AND REPAIR OF ADENOVIRUS DNA IN UV SENSITIVE CHINESE HAMSTER OVARY CELL MUTANTS. 312-312. 1991
- USE OF HERPES SIMPLEX VIRUS TYPE 1 AS A VECTOR FOR STUDYING THE EXPRESSION OF DNA REPAIR GENES IN MAMMALIAN CELLS. 334-334. 1991
- PRODUCTION OF VIRAL STRUCTURAL ANTIGENS BY IRRADIATED ADENOVIRUS AS AN ASSAY FOR DNA REPAIR IN HUMAN FIBROBLASTS. 541-545. 1978
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conferences
- Host cell reactivation of oxidative damaged DNA in human fibroblasts decreases with cell passage number in tissue culture but is not related to donor age. Mutagenesis. 545-545. 2009
- Upregulation of heat shock protein 27 plays a critical role in the resistance of HT29 cells to singlet oxygen-mediated photooxidation. Free Radical Biology and Medicine. S142-S142. 2001
- A quantitative polymerase chain reaction assay to examine host cell reactivation of a UV-damaged reporter gene in human cells.. Photochemistry and Photobiology. 88S-88S. 1999
- UV-enhanced reactivation of a UV-damaged reporter gene is promoter specific in human cells.. Photochemistry and Photobiology. 88S-89S. 1999
- Expression of the large T antigens of SV40 and polyomavirus sensitizes normal human diploid fibroblasts to UV and cisplatin.. The FASEB Journal. A1390-A1390. 1997
- Introduction of UV-damaged DNA into human tumour cells increases clonogenic survival following cisplatin treatment at low doses. The FASEB Journal. A1367-A1367. 1997
- Preferential excision repair in the transcribed strand of active genes is UV-inducible in human cells. RADIATION RESEARCH 1895-1995, CONGRESS PROCEEDINGS. 427-430. 1995
- Use of a Breast Phantom to Improve Image Quality and Patient Exposure in Ontario Mammography Facilities. Radiation Protection Dosimetry. 203-206. 1993
- Radiation Risk to the Patient: A Case Study Involving Multiple Diagnostic X Ray Exposures Given Over a Period of 25 Years. Radiation Protection Dosimetry. 221-224. 1992
- DIAGNOSIS OF THROMBOEMBOLIC DISEASE IN PREGNANT-WOMEN. Clinical Research. A411-A411. 1988
- LACK OF CORRELATION BETWEEN EXCISION REPAIR OF UV DAMAGE AND ADENOVIRUS REACTIVATION IN AN XP(D)-LIKE CELL-LINE. British Journal of Cancer. 352-352. 1986
- COMPARISON OF 2 HOSPITAL TUBERCULOSIS SURVEILLANCE PROGRAMS - RISKS AND BENEFITS. Medical decision making. 365-365. 1983
- RELATIVE REPAIR CAPACITIES FOR DNA DAMAGED BY UV-IRRADIATION, SUNLAMP-IRRADIATION AND GAMMA-RAYS IN XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME FIBROBLASTS. Radiation Research. 484-484. 1981
- UV ENHANCED REACTIVATION OF UV AND GAMMA-IRRADIATED ADENOVIRUS IN NORMAL, XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME FIBROBLASTS. Radiation Research. 484-485. 1981
- ENHANCED SURVIVAL OF IRRADIATED ADENOVIRUS IN XERODERMA PIGMENTOSUM AND COCKAYNES SYNDROME FIBROBLASTS. Radiation Research. 475-475. 1980
- REDUCED DNA-REPAIR IN HUNTINGTONS-CHOREA. Radiation Research. 475-476. 1980
- SENSITIVITY OF BLOOMS SYNDROME CELLS TO SPECIFIC MUTAGENS. Environmental Mutagenesis. 188-189. 1979
- DECREASED REPAIR OF GAMMA-RAY DAMAGED DNA IN XERODERMA PIGMENTOSUM FIBROBLASTS. Journal of supramolecular structure. 80-80. 1978
- GAMMA-RAY ENHANCED REACTIVATION OF UV-IRRADIATED ADENOVIRUS IN NORMAL HUMAN FIBROBLASTS. Radiation Research. 533-533. 1978
- PRODUCTION OF VIRAL STRUCTURAL ANTIGENS BY IRRADIATED ADENOVIRUS AS AN ASSAY FOR DNA-REPAIR IN HUMAN FIBROBLASTS. Journal of supramolecular structure. 35-35. 1978
- Viral DNA synthesis and virus production in human KB cells infected with gamma irradiated adenovirus. Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology. 135-135. 1977
- REDUCED HOST-CELL REACTIVATION OF UV-IRRADIATED ADENOVIRUS IN FANCONIS ANEMIA FIBROBLASTS. Radiation Research. 686-686. 1977
- REPAIR OF UV-INDUCED ALKALINE LABILE DNA DAMAGE IN ADENOVIRUS AFTER INFECTION OF SEVERAL HUMAN FIBROBLAST LINES. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 149-150. 1977
- SURVEY OF SOME FACTORS AFFECTING PATIENT EXPOSURE IN RADIOGRAPHY. Physics in Medicine and Biology. 585-585. 1977
- UV-TRANSCRIPTIONAL UNIT MAPPING IN ADENOVIRUS TYPE-2. Journal of supramolecular structure. 85-85. 1977
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journal articles
- Modulation of oxidative phosphorylation (OXPHOS) by radiation- induced biophotons. Environmental Research. 163:80-87. 2018
- An Observed Effect of p53 Status on the Bystander Response to Radiation-Induced Cellular Photon Emission. Radiation Research. 187:169-169. 2017
- Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: Reconciling the mechanisms mediating the bystander effect. PLoS ONE. 12:e0173685-e0173685. 2017
- Factors affecting ultraviolet-A photon emission from β-irradiated human keratinocyte cells. Physics in Medicine and Biology. 60:6371-6389. 2015
- An Observed Effect of Ultraviolet Radiation Emitted from Beta-Irradiated HaCaT Cells upon Non-Beta-Irradiated Bystander Cells. Radiation Research. 183:279-279. 2015
- Host cell reactivation of gene expression for an adenovirus-encoded reporter gene reflects the repair of UVC-induced cyclobutane pyrimidine dimers and methylene blue plus visible light-induced 8-oxoguanine. Mutagenesis. 28:507-513. 2013
- Reduced host cell reactivation of oxidatively damaged DNA in ageing human fibroblasts. Oncology Reports. 29:2493-2497. 2013
- Cockayne Syndrome group B protein interacts with TRF2 and regulates telomere length and stability. Nucleic Acids Research (NAR). 40:9661-9674. 2012
- A combination of MSH2 DNA mismatch repair deficiency and expression of the SV40 large T antigen results in cisplatin resistance of mouse embryonic fibroblasts. International Journal of Oncology. 39:719-726. 2011
- Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells. DNA Repair. 10:835-847. 2011
- Early host cell reactivation of an oxidatively damaged adenovirus-encoded reporter gene requires the Cockayne syndrome proteins CSA and CSB. Mutagenesis. 26:315-321. 2011
- Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells. DNA Repair. 8:370-382. 2009
- In Vitro Survival of Nonsmall Cell Lung Cancer Cells Following Combined Treatment with Ionizing Radiation and Photofrin‐mediated Photodynamic Therapy. Photochemistry and Photobiology. 85:99-106. 2009
- UV-inducible base excision repair of oxidative damaged DNA in human cells. Mutagenesis. 24:75-83. 2009
- Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts. DNA Repair. 7:617-632. 2008
- Expression of an adenovirus encoded reporter gene and its reactivation following UVC and oxidative damage in cultured fish cells. International Journal of Radiation Biology. 84:455-466. 2008
- Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts. Biochemical and Biophysical Research Communications. 359:1004-1009. 2007
- Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells. DNA Repair. 6:588-601. 2007
- Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross‐Resistance to UVA but not UVC Light. Photochemistry and Photobiology. 83:730-737. 2007
- Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2. Mutagenesis. 22:235-243. 2007
- XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. DNA Repair. 6:157-166. 2007
- Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells. Journal of Photochemistry and Photobiology B: Biology. 81:89-97. 2005
- Human cells deficient in transcription-coupled repair show prolonged activation of the Jun N-terminal kinase and increased sensitivity following cisplatin treatment. Cancer Chemotherapy and Pharmacology. 56:189-198. 2005
- Enhanced expression from the human cytomegalovirus immediate-early promoter in a non-replicating adenovirus encoded reporter gene following cellular exposure to chemical DNA damaging agents. Biochemical and Biophysical Research Communications. 332:441-449. 2005
- Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells. Biochemical and Biophysical Research Communications. 331:648-657. 2005
- Alterations in Mitochondrial and Apoptosis‐regulating Gene Expression in Photodynamic Therapy‐resistant Variants of HT29 Colon Carcinoma Cells¶. Photochemistry and Photobiology. 81:306-313. 2005
- Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶. Photochemistry and Photobiology. 81:306-306. 2005
- Pre-UV-Treatment of Cells Results in Enhanced Host Cell Reactivation of a UV Damaged Reporter Gene in CHO-AA8 Chinese Hamster Ovary Cells but Not in Transcription-Coupled Repair Deficient CHO-UV61 Cells. Bioscience Reports. 24:559-576. 2004
- Detection of an Involvement of the Human Mismatch Repair Genes hMLH1 and hMSH2 in Nucleotide Excision Repair Is Dependent on UVC Fluence to Cells. Cancer Research. 64:3865-3870. 2004
- Combined gamma‐irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin. International Journal of Radiation Biology. 80:291-299. 2004
- Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology. 71:77-85. 2003
- Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter¶. Photochemistry and Photobiology. 77:621-621. 2003
- Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.. Cancer Research. 62:5528-5535. 2002
- Up-regulation of Hsp27 Plays a Role in the Resistance of Human Colon Carcinoma HT29 Cells to Photooxidative Stress¶. Photochemistry and Photobiology. 76:98-98. 2002
- Estimating Radiation Exposure to the Patient. Radiology. 221:559-561. 2001
- Estimating radiation exposure to the patient - Response. Radiology. 221:559-561. 2001
- Induction of Hsp60 by Photofrin-mediated photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology. 64:55-61. 2001
- Extreme Dark Cytotoxicity of Nile Blue A in Normal Human Fibroblasts¶. Photochemistry and Photobiology. 74:707-707. 2001
- In Vitro Induction of PDT Resistance in HT29, HT1376 and SK-N-MC Cells by Various Photosensitizers¶. Photochemistry and Photobiology. 73:651-651. 2001
- Low-Dose Nonenhanced Helical CT of Renal Colic: Assessment of Ureteric Stone Detection and Measurement of Effective Dose Equivalent. Radiology. 215:51-54. 2000
- The Role of the p53 Tumor Suppressor in the Response of Human Cells to Photofrin-mediated Photodynamic Therapy. Photochemistry and Photobiology. 71:201-210. 2000
- Partial Complementation of the DNA Repair Defects in Cells from Xeroderma Pigmentosum Groups A, C, D and F but not G by the denV Gene from Bacteriophage T4¶. Photochemistry and Photobiology. 72:365-365. 2000
- UV-enhanced Expression of a Reporter Gene is Induced at Lower UV Fluences in Transcription-coupled Repair Deficient Compared to Normal Human Fibroblasts, and is Absent in SV40-transformed Counterparts¶. Photochemistry and Photobiology. 72:554-554. 2000
- Potential roles for p53 in nucleotide excision repair. Carcinogenesis. 20:1389-1396. 1999
- In vivo resistance to photofrin-mediated photodynamic therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology. 49:136-141. 1999
- Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene. 18:583-592. 1999
- Pre-exposure of human squamous carcinoma cells to low-doses of gamma-rays leads to an increased resistance to subsequent low-dose cisplatin treatment. International Journal of Radiation Biology. 75:963-972. 1999
- Removal of UV photoproducts from an adenovirus-encoded reporter gene following infection of unirradiated and UV-irradiated human fibroblasts.. Somatic Cell and Molecular Genetics. 25:301-315. 1999
- UV-enhanced reactivation of a UV-damaged reporter gene suggests transcription-coupled repair is UV-inducible in human cells. Carcinogenesis. 20:19-26. 1999
- Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis. Oncogene. 17:545-555. 1998
- Capacity of UV‐lrradiated Human Fibroblasts to Support Adenovirus DNA Synthesis Correlates with Transcription‐Coupled Repair and is Reduced in SV40‐Transformed Cells and Cells Expressing Mutant p53. Photochemistry and Photobiology. 66:659-664. 1997
- Incomplete complementation of the DNA repair defect in cockayne syndrome cells by the denV gene from bacteriophage T4 suggests a deficiency in base excision repair. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 385:59-74. 1997
- Cross-resistance to photofrin-mediated photodynamic therapy and UV light and recovery from photodynamic therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity. Journal of Photochemistry and Photobiology B: Biology. 38:143-151. 1997
- Requesting diagnostic imaging examinations: a position paper of the Canadian Association of Radiologists.. Canadian Association of Radiologists Journal. 48:89-91. 1997
- Wildtype p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene. Carcinogenesis. 18:245-249. 1997
- Survival, mutagenesis, and host cell reactivation in a Chinese hamster ovary cell ERCC1 knock-out mutant. Mutagenesis. 12:277-283. 1997
- Host cell reactivation of cisplatin-treated adenovirus is reduced in nucleotide excision repair deficient mammalian cells and several human tumour cells. International Journal of Oncology. 9:1121-1127. 1996
- Roberts syndrome fibroblasts showing cisplatin hypersensitivity have normal host cell reactivation of cisplatin-treated adenovirus and normal capacity of cisplatin-treated cells for adenovirus DNA synthesis. Somatic Cell and Molecular Genetics. 22:393-402. 1996
- Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 363:125-135. 1996
- Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*). Cancer Chemotherapy and Pharmacology. 38:245-253. 1996
- Host cell reactivation of irradiated adenovirus in UV-sensitive Chinese hamster ovary cell mutants. Mutagenesis. 11:89-94. 1996
- Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells. Journal of Virology. 68:834-845. 1994
- A limited, low-dose computed tomography protocol to examine the sacroiliac joints.. Canadian Association of Radiologists Journal. 44:267-272. 1993
- Homologous recombination of adenovirus DNA in mammalian cells: enhanced recombination following UV-irradiation of the virus. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 274:201-210. 1992
- Construction of a recombinant adenovirus containing the den V gene from bacteriophage T4 which can partially restore the DNA repair deficiency in xeroderma pigmentosum fibroblasts. Carcinogenesis. 12:249-255. 1991
- Host cell reactivation of sunlamp‐exposed adenovirus in fibroblasts from patients with bloom's syndrome, ataxia telangiectasia, and huntington's disease. Environmental and Molecular Mutagenesis. 17:98-103. 1991
- Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet‐irradiated herpes simplex virus in human cells. Environmental and Molecular Mutagenesis. 15:19-23. 1990
- Role of the viral and cellular encoded thymidine kinase in the repair of UV-irradiated herpes simplex virus. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 227:263-267. 1989
- Thymidine kinase deficient human cells have increased UV sensitivity in their capacity to support herpes simplex virus but normal UV sensitivity for colony formation. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 218:189-196. 1989
- DNA Damage and Biological Expression of Adenovirus: A Comparison of Liquid versus Frozen Conditions of Exposure to γ Rays. Radiation Research. 120:102-102. 1989
- RELATIVE REPAIR OF ADENOVIRUS DAMAGED BY SUNLAMP, UV AND γ‐IRRADIATION IN COCKAYNE SYNDROME FIBROBLASTS IS DIFFERENT FROM THAT IN XERODERMA PIGMENTOSUM FIBROBLASTS. Photochemistry and Photobiology. 50:201-207. 1989
- Defective repair of UV-damaged DNA in human tumor and SV40-transformed human cells but not in adenovirus-transformed human cells. Carcinogenesis. 10:1073-1077. 1989
- Risks to the Fetus of Radiologic Procedures Used in the Diagnosis of Maternal Venous Thromboembolic Disease. Thrombosis and Haemostasis. 61:189-196. 1989
- Delayed expression of enhanced reactivation and decreased mutagenesis of UV-irradiated adenovirus in UV-irradiated ataxia telangiectasia fibroblasts. Mutagenesis. 3:389-395. 1988
- Enhanced reactivation and mutagenesis of UV-irradiated adenovirus in normal human fibroblasts. Mutagenesis. 3:157-164. 1988
- Comparative studies of host-cell reactivation, cellular capacity and enhanced reactivation of herpes simplex virus in normal, xeroderma pigmentosum and Cockayne syndrome fibroblasts. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 166:99-111. 1986
- An aberration in gamma-ray-enhanced reactivation of irradiated adenovirus in ataxia telangiectasia fibroblasts. Carcinogenesis. 7:381-387. 1986
- Analysis of DNA repair in XP–HeLa hybrids; lack of correlation between excision repair of u.v. damage and adenovirus reactivation in an XP(D)-like cell line. Carcinogenesis. 7:1733-1738. 1986
- Xeroderma pigmentosum d-hela hybrids with low and high ultraviolet sensitivity associated with normal and diminished dna repair ability, respectively. Journal of Cell Science. 76:115-133. 1985
- Comparison of two hospital tuberculosis surveillance programs: risks and benefits.. Canadian Journal of Public Health. 76:237-243. 1985
- Gamma-Ray-Enhanced Reactivation of Irradiated Adenovirus in Xeroderma Pigmentosum and Cockayne Syndrome Fibroblasts. Radiation Research. 94:480-480. 1983
- U.V. Enhanced Reactivation of U.V.- and γ-irradiated Adenovirus in Cockayne Syndrome and Xeroderma Pigmentosum Fibroblasts. International Journal of Radiation Biology. 43:625-647. 1983
- U.V. Enhanced Reactivation of U.V.- and γ-irradiated Adenovirus in Normal Human Fibroblasts. International Journal of Radiation Biology. 43:599-623. 1983
- A deficiency in the repair of UV and γ-ray damaged DNA in fibroblasts from Cockayne's syndrome. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 93:235-247. 1982
- Reduced capacity to repair irradiated adenovirus in fibroblasts from xeroderma pigmentosum heterozygotes.. Cancer Research. 40:3945-3949. 1980
- A rapid and efficient procedure for the purification of DNA from agarose gels. Analytical Biochemistry. 106:492-496. 1980
- Studies on the ultraviolet light sensitivity of Bloom's syndrome fibroblasts. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 69:357-368. 1980
- γ-Ray enhanced reactivation of γ-irradiated adenovirus in human cells. Biochemical and Biophysical Research Communications. 90:567-574. 1979
- γ-ray-enhanced reactivation of UV-irradiated adenovirus in normal human fibroblasts. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 60:33-41. 1979
- Decreased Repair of Gamma-irradiated Adenovirus inXeroderma PigmentosumFibroblasts. International Journal of Radiation Biology. 36:621-629. 1979
- Ultraviolet transcriptional unit mapping for the late genes in adenovirus type 2. Virology. 84:75-86. 1978
- UV‐INDUCED ALKALINE LABILE DNA DAMAGE IN HUMAN ADENOVIRUS AND ITS REPAIR AFTER INFECTION OF HUMAN CELLS. Photochemistry and Photobiology. 25:457-463. 1977
- Decreased repair of gamma ray damaged DNA in progeria. Biochemical and Biophysical Research Communications. 74:714-719. 1977
- Defective Repair of Ultraviolet- and Gamma-ray-damaged DNA in Fanconi's Anaemia. International Journal of Radiation Biology. 31:191-195. 1977
- Host-Cell Reactivation of Irradiated Human Adenovirus. Basic Life Sciences. 5B:753-754. 1975
- Repair of Radiation-Induced DNA Breaks in Human Adenovirus. Radiation Research. 60:155-155. 1974
- DNA Damage and Biological Function of Human Adenovirus after U.V.-irradiation. International Journal of Radiation Biology. 24:59-72. 1973
- DNA Strand Breakage and Biological Functions of Human Adenovirus after Gamma Irradiation. Radiation Research. 50:319-319. 1972
- Functional Heterogeneity of Virions in Human Adenovirus Types 2 and 12. Journal of Virology. 5:188-193. 1970
- Up-regulation of Hsp27 Plays a Role in the Resistance of Human Colon Carcinoma HT29 Cells to Photooxidative Stress¶. Photochemistry and Photobiology. 76:98-104.
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theses