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Ca(2+)-dependent Cl- current in canine tracheal...

Journal article

Ca(2+)-dependent Cl- current in canine tracheal smooth muscle cells

Abstract

Our goal was to investigate the role of Ca2+ entry in regulating Cl- current (ICl) in smooth muscle cells from canine trachealis. When studies were done using the perforated patch configuration, depolarization elicited a dihydropyridine-sensitive Ca2+ current (ICa), followed in many cells by a sustained current. This sustained current reversed direction close to the Cl- equilibrium potential, consistent with its representing ICl. The ICl was …

Authors

Janssen LJ; Sims SM

Journal

American Journal of Physiology-Cell Physiology, Vol. 269, No. 1, pp. C163–C169

Publisher

American Physiological Society

Publication Date

July 1, 1995

DOI

10.1152/ajpcell.1995.269.1.c163

ISSN

0363-6143

Associated Experts

Luke Jeffrey Janssen

Professor Emeritus, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Acetylcholine Animals Calcium Calcium Channels Chloride Channels Chlorides Dogs Electric Conductivity Electrophysiology Muscle, Smooth Trachea

Fields of Research (FoR)

3101 Biochemistry and cell biology 3208 Medical physiology

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