Journal article
Differential Mechanisms Targeting Type 1 Plasminogen Activator Inhibitor and Vitronectin Into the Storage Granules of a Human Megakaryocytic Cell Line
Abstract
Type 1 plasminogen activator inhibitor (PAI-1) and its cofactor vitronectin (Vn) are stored within the alpha-granules of platelets. The two possible sources for their biosynthetic origin are endogenous synthesis in megakaryocytes or endocytosis from plasma. Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate …
Authors
Hill SA; Shaughnessy SG; Joshua P; Ribau J; Austin RC; Podor TJ
Journal
Blood, Vol. 87, No. 12, pp. 5061–5073
Publisher
American Society of Hematology
Publication Date
June 15, 1996
DOI
10.1182/blood.v87.12.5061.bloodjournal87125061
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Base SequenceBiological TransportCarcinoma, HepatocellularCell DifferentiationCytoplasmic GranulesEndocytosisHumansLeukemia, Megakaryoblastic, AcuteLiver NeoplasmsMegakaryocytesMicroscopy, ConfocalMolecular Sequence DataNeoplasm ProteinsPlasminogen Activator Inhibitor 1RNA, MessengerRNA, NeoplasmTetradecanoylphorbol AcetateTumor Cells, CulturedVacuolesVitronectin