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Cumulating evidence from randomized trials:...
Journal article

Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis

Abstract

We propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative …

Authors

Pogue JM; Yusuf S

Journal

Contemporary Clinical Trials, Vol. 18, No. 6, pp. 580–593

Publisher

Elsevier

Publication Date

12 1997

DOI

10.1016/s0197-2456(97)00051-2

ISSN

1551-7144