Journal article
Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study
Abstract
BACKGROUND: Previous trials in the prevention of heart failure have been restricted to patients with low ejection fraction or hypertension. We assessed an angiotensin-converting enzyme (ACE) inhibitor, ramipril, to prevent the development of heart failure in high-risk patients without known low ejection fraction or heart failure.
METHODS AND RESULTS: We randomly assigned 9297 patients to receive double-blind ramipril (10 mg daily) or matching …
Authors
Arnold JMO; Yusuf S; Young J; Mathew J; Johnstone D; Avezum A; Lonn E; Pogue J; Bosch J
Journal
Circulation, Vol. 107, No. 9, pp. 1284–1290
Publisher
Wolters Kluwer
Publication Date
March 11, 2003
DOI
10.1161/01.cir.0000054165.93055.42
ISSN
0009-7322