Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome

A 45‐year‐old female was diagnosed with Hashimoto’s thyroiditis in 1976 and Addison’s disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. A liver biopsy confirmed the diagnosis of primary biliary cirrhosis (PBC). She underwent a liver transplantation in January 1998. This is the first report of PBC in association with type II autoimmune polyglandular syndrome. The association of PBC with other organ‐specific autoimmune diseases supports an immune‐mediated pathogenesis and may have implications in further studies of PBC.

Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome Journal Articles