d-penicillamine: Chemistry and clinical use in rheumatic disease Journal Articles uri icon

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  • The discovery of D-penicillamine and its uses in medicine are reviewed. Chemical-physical properties are discussed, and the molecular structure of D-penicillamine and several of its reaction products are illustrated. Examples of its three main types of biochemical reactions--sulfhydryl-disulfide exchange, thiazolidine formation, and metal chelation are included. Trials of D-penicillamine in RA patients are reviewed critically. The administration of the drug is discussed in detail, including dosages, clinical and laboratory responses, patterns of adverse side effects or toxicity, drug-induced autoimmune diseases, indications and contraindications, and the monitoring and management of patients.


  • Howard-Lock, Helen E
  • Lock, Colin JL
  • Mewa, Amirudin
  • Kean, Walter

publication date

  • May 1986

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