Journal article
Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes
Abstract
Autism spectrum disorders (ASDs) are genetically and clinically heterogeneous and lack effective medications to treat their core symptoms. Studies of syndromic ASDs caused by single gene mutations have provided insights into the pathophysiology of autism. Fragile X and Rett syndromes belong to the syndromic ASDs in which preclinical studies have identified rational targets for drug therapies focused on correcting underlying neural dysfunction. …
Authors
Wang H; Pati S; Pozzo-Miller L; Doering LC
Journal
Frontiers in Cellular Neuroscience, Vol. 9, ,
Publisher
Frontiers
DOI
10.3389/fncel.2015.00055
ISSN
1662-5102