Journal article
Ciliary neurotrophic factor protects retinal ganglion cells from axotomy‐induced apoptosis via modulation of retinal glia in vivo
Abstract
Adenoviral-mediated transfer of ciliary neurotrophic factor (CNTF) to the retina rescued retinal ganglion cells (RGCs) from axotomy-induced apoptosis, presumably via activation of the high affinity CNTF receptor alpha (CNTFRalpha) expressed on RGCs. CNTF can also activate astrocytes, via its low affinity leukemia inhibitory receptor beta expressed on mature astrocytes, suggesting that CNTF may also protect injured neurons indirectly by …
Authors
van Adel BA; Arnold JM; Phipps J; Doering LC; Ball AK
Journal
Developmental Neurobiology, Vol. 63, No. 3, pp. 215–234
Publisher
Wiley
Publication Date
June 2005
DOI
10.1002/neu.20117
ISSN
1932-8451