Asthma pathogenesis and allergen-induced late responses

Increases in airway eosinophils occur during the late asthmatic response, 7 hours after allergen inhalation, and these can persist for 3 days. Also, increases in airway metachromatic cells occur which are most marked after 7 hours. These increases in airway cells are associated with increases in bone marrow progenitors, which are caused by an increased responsiveness of the bone marrow to IL-5 after allergen because of an increased expression …