Journal article
Diazepam Inhibits Forskolin‐Stimulated Adenylyl Cyclase Activity in Human Tumour Cells
Abstract
Previous studies have shown that the benzodiazepine agonist, diazepam, suppresses adenylyl cyclase activity in rat brain, via a G protein-coupled benzodiazepine receptor. Since diazepam binding sites are also present in diverse non-neuronal tissues including tumour cells, its effects on adenylyl cyclase activity were examined in membranes from human MCF-7 (breast cancer) and M-6 (melanoma) cells. Diazepam caused a biphasic and …
Authors
Niles LP; Wang J
Journal
Basic & Clinical Pharmacology & Toxicology, Vol. 85, No. 6, pp. 153–156
Publisher
Wiley
Publication Date
12 1999
DOI
10.1111/j.1600-0773.1999.tb00084.x
ISSN
1742-7835