Journal article
Induction of Neurotrophic and Differentiation Factors in Neural Stem Cells by Valproic Acid
Abstract
Valproic acid (VPA), a short-chain fatty acid, is used clinically as an anticonvulsant and mood stabilizer. Valproic acid also inhibits histone deacetylase activity, which is associated with histone hyperacetylation and changes in gene expression. In this study, we examined the effects of VPA on the expression of selected neurotrophic and differentiation factors in C17.2 neural stem cells. Reverse transcription-polymerase chain reaction …
Authors
Almutawaa W; Kang NH; Pan Y; Niles LP
Journal
Basic & Clinical Pharmacology & Toxicology, Vol. 115, No. 2, pp. 216–221
Publisher
Wiley
Publication Date
August 2014
DOI
10.1111/bcpt.12201
ISSN
1742-7835
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntimanic AgentsCell LineDose-Response Relationship, DrugEpigenesis, GeneticGene Expression RegulationGlial Cell Line-Derived Neurotrophic FactorHistone Deacetylase InhibitorsMiceNerve Growth FactorsNeural Stem CellsRNA, MessengerReverse Transcriptase Polymerase Chain ReactionTime FactorsValproic Acid