Generation of reactive oxygen species and formation of membrane lipid peroxides in cells infected with Chlamydia trachomatis

OBJECTIVES: Chlamydiae are obligate intracellular pathogens that cause many diseases for which the pathogenic mechanisms are largely unknown. Because reactive oxygen species (ROS) have been implicated in pathogenesis of many viral and bacterial infections, the authors assessed the release of ROS in selected host cells (monocytes, Sup-T1 cells, and Hep-2 cells) infected with Chlamydia trachomatis. METHODS: Infected cell cultures demonstrated a …