Journal article
Diphtheria toxin resistance in chinese hamster cells: Genetic and biochemical characteristics of the mutants affected in protein synthesis
Abstract
Diphtheria toxin (DT) resistant mutants (Dipr) have been isolated from a number of different Chinese hamster lines. Among mutants affected in protein synthesis (DiprII class), two distinct phenotypes have been identified. In one class, the entire elongation factor-2 (EF-2) activity becomes resistant to DT-catalyzed ADP-ribosylation (DiprIIa class); these mutants behave recessively upon hybridization with sensitive cells. The second kind of …
Authors
Gupta RS; Siminovitch L
Journal
Somatic Cell Genetics, Vol. 6, No. 3, pp. 361–379
Publisher
Springer Nature
Publication Date
May 1980
DOI
10.1007/bf01542789
ISSN
0098-0366