Journal article
Resistance to the microtubule inhibitor podophyllotoxin: Selection and partial characterization of mutants in CHO cells
Abstract
Stable mutants two- to fourfold more resistant to the microtubule inhibitor podophyllotoxin (PodRI)have been selected in a single step in Chinese hamster ovary (CHO) cells. Mutants showing higher levels of resistance to the drug can be obtained in a second-step selection using the PodRImutants (PodRIIclass).Prior treatment of cells with the mutagen ethylmethane sulfonate markedly enhanced the frequency of both PodRIand PodRIImutants in culture. …
Authors
Gupta RS
Journal
Somatic Cell Genetics, Vol. 7, No. 1, pp. 59–71
Publisher
Springer Nature
Publication Date
January 1981
DOI
10.1007/bf01544748
ISSN
0098-0366