Journal article
Quantitative mutagenesis at the adenosine kinase locus in Chinese hamster ovary cells Development and characteristics of the selection system
Abstract
Stable mutants exhibiting high degree of resistance (100-1000-fold) to various nucleoside analogs viz, toyocamycin, tubercidin, 6-methyl mercaptopurine riboside (6-MeMPR) and pyrazofurin, are obtained at similar frequency (congruent to 1 X 10(-4] in CHO cells. The mutants resistant to any of the above analogs exhibit similar degree of cross-resistance to the other three nucleoside analogs, and all of the mutants examined contained no measurable …
Authors
Gupta RS; Singh B
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 113, No. 5, pp. 441–454
Publisher
Elsevier
Publication Date
August 1983
DOI
10.1016/0165-1161(83)90233-9
ISSN
0027-5107