Journal article
Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II
Abstract
The role of DNA topoisomerase II in multifactorial resistance to antineoplastic agents is reviewed. We have previously observed that in Adriamycin (ADR) resistant P388 murine leukemia cells, DNA topoisomerase II enzyme content and cleavage and catalytic activities were all reduced and correlated with drug sensitivity. A subsequent study provided evidence for an allelic mutation of the gene for DNA topoisomerase II as a possible molecular …
Authors
Deffie AM; McPherson JP; Gupta RS; Hedley DW; Goldenberg GJ
Journal
Biochemistry and Cell Biology, Vol. 70, No. 5, pp. 354–364
Publisher
Canadian Science Publishing
Publication Date
May 1, 1992
DOI
10.1139/o92-055
ISSN
0829-8211