Microenvironmental influences on inflammatory cell differentiation Journal Articles

abstract

• Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which can influence the differentiation of inflammatory cell progenitors. It is particular mechanism that we have investigated, showing that molecules such as GM‐CSF, G‐CSF, IL‐6, IL‐8 and SCF can be produced by airways epithelial cells and fibroblasts in quantities sufficient to induce hemopoietic events, either systemically or locally. Corticosteriods may act therapeutically, at least in part, to block inflammatory cell differentiation, and thus recruitment, into the allergic inflammatory process in the airways.

authors

• Denburg, Judah Aryeh

status

• published 

publication date

• June 1995

has subject area

• Adrenal Cortex Hormones (MeSH)
• Cell Differentiation (MeSH)
• Cytokines (MeSH)
• Humans (MeSH)
• Hypersensitivity (MeSH)
• Inflammation (MeSH)
• Respiratory System (MeSH)

published in

• Acta Allergologica  Journal

keywords

• Adrenal Cortex Hormones
• Cell Differentiation
• Cytokines
• Humans
• Hypersensitivity
• Inflammation
• Respiratory System

Digital Object Identifier (DOI)

• 10.1111/j.1398-9995.1995.tb04272.x

PubMed ID

• 7677230

start page

• 25

end page

• 28

volume

• 50

issue

• s25