Journal article
Withdrawal From Long-term High-Dose Desipramine Therapy: Clinical and Biological Changes
Abstract
Investigation was undertaken on a patient whose long-term intake of desipramine hydrochloride was amongst the highest reported. Desipramine treatment instituted at a daily dosage of 75 mg for depressive equivalents of head, chest, and abdominal pain was increased to 1,000 mg daily over a 12-year interval with minimal side effects. Plasma desipramine level dropped immediately on withdrawal, and urinary metabolite values dropped over the …
Authors
Brown GM; Stancer HC; Moldofsky H; Harman J; Murphy JT; Gupta RN
Journal
JAMA Psychiatry, Vol. 35, No. 10, pp. 1261–1264
Publisher
American Medical Association (AMA)
Publication Date
October 1, 1978
DOI
10.1001/archpsyc.1978.01770340111012
ISSN
2168-622X